Integration of Transcriptomic Profiling, Genome-wide Association, and Network Biology Reveals Molecular Mechanisms Underlying Blood Pressure Regulation
نویسندگان
چکیده
Tianxiao Huan, Qingying Meng, Mohamed A. Saleh, Allison E. Norlander, Roby Joehanes, Jun Zhu, Brian H. Chen, Bin Zhang, Andrew D. Johnson, Saixia Ying, Paul Courchesne, Nalini Raghavachari, Richard Wang, Poching Liu, The International Consortium for Blood Pressure GWAS (ICBP), Christopher J. O'Donnell, Ramachandran Vasan, Peter J. Munson, Meena S. Madhur, David G. Harrison, Xia Yang, and Daniel Levy
منابع مشابه
Integrative network analysis reveals molecular mechanisms of blood pressure regulation
Genome-wide association studies (GWAS) have identified numerous loci associated with blood pressure (BP). The molecular mechanisms underlying BP regulation, however, remain unclear. We investigated BP-associated molecular mechanisms by integrating BP GWAS with whole blood mRNA expression profiles in 3,679 individuals, using network approaches. BP transcriptomic signatures at the single-gene and...
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